Honokiol inhibits gastric cancer via tumor microenvironment modulation: a bioinformatics and single-cell analysis
8.0
来源：
Nature
关键字：
mRNA
发布时间：
2025-11-26 04:00
摘要：
Honokiol, a natural polyphenol, demonstrates significant antitumor effects against gastric cancer by modulating the tumor microenvironment and inhibiting key signaling pathways, particularly through the regulation of CHUK. This study utilizes bioinformatics and single-cell analysis to uncover the molecular mechanisms underlying honokiol's therapeutic potential, suggesting its role as a promising candidate for innovative treatment strategies in gastric cancer.
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关键证据
Honokiol exerts multi-target and multi-pathway effects in gastric cancer.
CHUK is identified as a key hub gene in the treatment mechanism.
The study integrates bioinformatics and experimental validation to support findings.
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AI评分总结
Honokiol, a natural polyphenol, demonstrates significant antitumor effects against gastric cancer by modulating the tumor microenvironment and inhibiting key signaling pathways, particularly through the regulation of CHUK. This study utilizes bioinformatics and single-cell analysis to uncover the molecular mechanisms underlying honokiol's therapeutic potential, suggesting its role as a promising candidate for innovative treatment strategies in gastric cancer.