Ailanthone restrains hepatocellular carcinoma progression by inducing ferroptosis and disrupting mitochondrial homeostasis
9.5
来源：
Nature
关键字：
mRNA
发布时间：
2025-11-26 04:00
摘要：
Ailanthone (AIL), a natural compound, effectively inhibits hepatocellular carcinoma (HCC) progression by inducing ferroptosis and disrupting mitochondrial homeostasis. The study reveals that AIL interacts with HSP90, promoting the degradation of GPX4, a key regulator of ferroptosis. In vitro and in vivo experiments demonstrate AIL's potential as a novel therapeutic agent against HCC, especially when combined with GPX4 inhibitors, showcasing a promising avenue for cancer treatment.
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关键证据
AIL significantly inhibits HCC cell proliferation and migration.
Mechanistically, AIL interacts with HSP90, leading to GPX4 degradation.
Combining AIL with GPX4 inhibitors exhibits a strong synergistic anti-proliferative effect.
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AI评分总结
Ailanthone (AIL), a natural compound, effectively inhibits hepatocellular carcinoma (HCC) progression by inducing ferroptosis and disrupting mitochondrial homeostasis. The study reveals that AIL interacts with HSP90, promoting the degradation of GPX4, a key regulator of ferroptosis. In vitro and in vivo experiments demonstrate AIL's potential as a novel therapeutic agent against HCC, especially when combined with GPX4 inhibitors, showcasing a promising avenue for cancer treatment.