Gestational hypothyroxinemia causes an inflammatory environment at maternal-fetal tissues and fetal brain with impaired hippocampal dendritic spine maturation in the offspring
8.0
来源：
Nature
关键字：
ML brain science
发布时间：
2025-11-27 03:37
摘要：
Gestational hypothyroxinemia (HTX) is linked to cognitive impairments and autism traits in offspring. This study demonstrates that HTX induces a pro-inflammatory environment characterized by elevated IL-6 and IL-17 A levels, leading to impaired fetal brain development. The findings suggest that maintaining adequate maternal thyroid hormone levels is crucial for preventing neurodevelopmental disorders in offspring. Restoring T4 levels during HTX induction mitigated these adverse effects, highlighting the importance of thyroid hormones in prenatal health.
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关键证据
Gestational hypothyroxinemia causes inflammation during pregnancy and has neurodevelopmental effects on the progeny.
Restoring T4 levels during HTX induction prevented alterations during pregnancy and in the offspring.
Elevated levels of IL-6 and IL-17 A were found in maternal serum, placental tissues, and embryonic brains.
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AI评分总结
Gestational hypothyroxinemia (HTX) is linked to cognitive impairments and autism traits in offspring. This study demonstrates that HTX induces a pro-inflammatory environment characterized by elevated IL-6 and IL-17 A levels, leading to impaired fetal brain development. The findings suggest that maintaining adequate maternal thyroid hormone levels is crucial for preventing neurodevelopmental disorders in offspring. Restoring T4 levels during HTX induction mitigated these adverse effects, highlighting the importance of thyroid hormones in prenatal health.