EZH2 expression in hepatocellular carcinoma and its relationship with circadian rhythm-related genes
8.5
来源：
Nature
关键字：
mRNA
发布时间：
2025-11-27 03:52
摘要：
The study investigates the role of EZH2 in hepatocellular carcinoma (HCC), revealing its overexpression correlates with advanced tumor stages and poor patient prognosis. It establishes a link between EZH2 and circadian rhythm-related genes, suggesting that EZH2 may influence tumor progression through these pathways. The research utilizes data from TCGA and GEO databases, highlighting the potential of EZH2 as a prognostic biomarker and therapeutic target in HCC, with implications for personalized medicine.
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关键证据
EZH2 was overexpressed in HCC and associated with advanced tumor stage and poor prognosis.
A prognostic nomogram integrating EZH2 expression demonstrated strong predictive performance.
EZH2 knockdown inhibited proliferation and induced DNA damage in HCC cells.
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AI评分总结
The study investigates the role of EZH2 in hepatocellular carcinoma (HCC), revealing its overexpression correlates with advanced tumor stages and poor patient prognosis. It establishes a link between EZH2 and circadian rhythm-related genes, suggesting that EZH2 may influence tumor progression through these pathways. The research utilizes data from TCGA and GEO databases, highlighting the potential of EZH2 as a prognostic biomarker and therapeutic target in HCC, with implications for personalized medicine.