CCDC141 is a Connectin/Titin and Nesprin-1 binding protein that adapts cardiomyocytes to mechanical stress
8.4
来源：
Nature
关键字：
mRNA
发布时间：
2025-11-27 03:54
摘要：
CCDC141 is identified as a novel binding protein that interacts with connectin and nesprin-1, playing a critical role in the adaptation of cardiomyocytes to mechanical stress. The knockout of CCDC141 leads to significant cardiac dysfunction, including hypertrophy and increased susceptibility to fatal arrhythmias under mechanical stress. This research highlights CCDC141's potential as a therapeutic target for improving cardiac function in heart diseases.
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关键证据
CCDC141-KO hearts show low tolerance to mechanical stress and increased susceptibility to fatal arrhythmias.
CCDC141 interacts with connectin and nesprin-1, crucial for cardiac mechanoadaptation.
Genome-wide association studies link CCDC141 to various cardiac traits, suggesting its therapeutic potential.
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AI评分总结
CCDC141 is identified as a novel binding protein that interacts with connectin and nesprin-1, playing a critical role in the adaptation of cardiomyocytes to mechanical stress. The knockout of CCDC141 leads to significant cardiac dysfunction, including hypertrophy and increased susceptibility to fatal arrhythmias under mechanical stress. This research highlights CCDC141's potential as a therapeutic target for improving cardiac function in heart diseases.