Sesamol regulates AQP3 and HAS2 via MAPK signaling for skin barrier protection an in vitro and molecular docking study
6.5
来源：
Nature
关键字：
mRNA
发布时间：
2025-11-27 23:36
摘要：
Sesamol, a food-derived compound, has been shown to enhance skin barrier integrity by regulating AQP3 and HAS2 through the MAPK signaling pathway. This study highlights sesamol's potential in combating photoaging and inflammatory skin disorders, demonstrating its effectiveness in UVB-induced and TNF-α-induced skin damage models. The findings suggest significant implications for skin health and potential therapeutic applications.
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关键证据
Sesamol regulates the expression of aquaporin-3 (AQP3) and hyaluronan synthase 2 (HAS2) in HaCaT keratinocytes.
In UVB-induced photoaging models, sesamol effectively suppressed hyaluronidase mRNA expression.
Molecular docking experiments validated stable interactions between sesamol and key proteins.
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AI评分总结
Sesamol, a food-derived compound, has been shown to enhance skin barrier integrity by regulating AQP3 and HAS2 through the MAPK signaling pathway. This study highlights sesamol's potential in combating photoaging and inflammatory skin disorders, demonstrating its effectiveness in UVB-induced and TNF-α-induced skin damage models. The findings suggest significant implications for skin health and potential therapeutic applications.