Fibrinogen alpha and beta chains as non-invasive predictors of hepatocellular carcinoma progression
8.0
来源：
Nature
关键字：
mRNA
发布时间：
2025-11-28 03:50
摘要：
Fibrinogen alpha (FGA) and beta (FGB) chains have been identified as promising non-invasive biomarkers for hepatocellular carcinoma (HCC), showing improved diagnostic accuracy compared to traditional markers like α-fetoprotein (AFP). The study highlights significant downregulation of these proteins in HCC, correlating with disease progression and overall survival rates. Their consistent expression patterns across various stages of HCC suggest their potential utility in early diagnosis and monitoring of the disease. The findings underscore the importance of further research to validate these biomarkers in clinical settings.
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关键证据
FGA and FGB demonstrated higher diagnostic accuracies than AFP.
The study identified a consistent downregulation of fibrinogen family members in HCC.
Fibrinogen levels correlated negatively with myeloid-derived suppressor cells in the tumor microenvironment.
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AI评分总结
Fibrinogen alpha (FGA) and beta (FGB) chains have been identified as promising non-invasive biomarkers for hepatocellular carcinoma (HCC), showing improved diagnostic accuracy compared to traditional markers like α-fetoprotein (AFP). The study highlights significant downregulation of these proteins in HCC, correlating with disease progression and overall survival rates. Their consistent expression patterns across various stages of HCC suggest their potential utility in early diagnosis and monitoring of the disease. The findings underscore the importance of further research to validate these biomarkers in clinical settings.