Cathepsin B as a potential serum biomarker for early diagnosis and progression of diabetic foot ulcer complicated with peripheral vascular disease
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来源：
Nature
关键字：
mRNA
发布时间：
2025-11-28 03:51
摘要：
CTSB is proposed as a potential serum biomarker for early diagnosis of diabetic foot ulcer (DFU) complicated with peripheral vascular disease (PVD). The study reveals that CTSB levels correlate with the severity of DFU, as indicated by the Wagner grade, and its expression is linked to key clinical indicators. Functional assays demonstrate that CTSB influences angiogenesis in vascular endothelial cells, suggesting its role in disease progression. This research highlights the potential of CTSB for non-invasive monitoring and early intervention in DFU patients.
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关键证据
CTSB was identified as a significantly differentially expressed gene in vascular endothelial cells.
CTSB expression is positively correlated with clinical indicators of DFU and PVD.
CTSB can be detected in serum, making it a potential candidate for non-invasive biomarker screening.
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AI评分总结
CTSB is proposed as a potential serum biomarker for early diagnosis of diabetic foot ulcer (DFU) complicated with peripheral vascular disease (PVD). The study reveals that CTSB levels correlate with the severity of DFU, as indicated by the Wagner grade, and its expression is linked to key clinical indicators. Functional assays demonstrate that CTSB influences angiogenesis in vascular endothelial cells, suggesting its role in disease progression. This research highlights the potential of CTSB for non-invasive monitoring and early intervention in DFU patients.