CAR-macrophages in solid tumors: promise, progress, and prospects
8.0
来源：
Nature
关键字：
mRNA
发布时间：
2025-11-28 03:51
摘要：
CAR-macrophages (CAR-Ms) are emerging as a promising immunotherapy for solid tumors, combining the innate capabilities of macrophages with engineered chimeric antigen receptors (CARs). This article reviews the progress in CAR-M technology, including preclinical findings and ongoing clinical trials, which suggest a favorable safety profile and potential efficacy against solid tumors. Challenges such as in vivo persistence and scalability are discussed, alongside innovative strategies to enhance CAR-M functionality and address these hurdles. The future of CAR-M therapies looks promising as they advance through clinical testing, potentially transforming cancer treatment.
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domain_focus
1.0分+1.0分
business_impact
0.8分+0.8分
scientific_rigor
1.5分+1.5分
timeliness_innovation
1.5分+1.5分
investment_perspective
2.5分+2.5分
market_value_relevance
1.0分+1.0分
team_institution_background
0.5分+0.5分
technical_barrier_competition
1.0分+1.0分
关键证据
CAR-M therapy shows significant promise for treating solid tumors.
Recent clinical trials indicate a favorable safety profile and preliminary antitumor activity.
The article highlights technological innovations necessary for CAR-M clinical success.
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AI评分总结
CAR-macrophages (CAR-Ms) are emerging as a promising immunotherapy for solid tumors, combining the innate capabilities of macrophages with engineered chimeric antigen receptors (CARs). This article reviews the progress in CAR-M technology, including preclinical findings and ongoing clinical trials, which suggest a favorable safety profile and potential efficacy against solid tumors. Challenges such as in vivo persistence and scalability are discussed, alongside innovative strategies to enhance CAR-M functionality and address these hurdles. The future of CAR-M therapies looks promising as they advance through clinical testing, potentially transforming cancer treatment.