SKP2 protein as a prognostic biomarker for glioma and promotes tumor progression by regulating the cell cycle
8.5
来源：
Nature
关键字：
ML brain science
发布时间：
2025-11-28 23:36
摘要：
SKP2 protein plays a critical role in glioma progression by regulating the cell cycle. This study reveals that high SKP2 expression correlates with poor prognosis in glioma patients, suggesting its potential as a prognostic biomarker and therapeutic target. Analysis of data from TCGA and CGGA databases supports the association of SKP2 with adverse clinical features and survival outcomes, highlighting its significance in glioma biology.
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关键证据
SKP2 expression is positively correlated with adverse clinical features of gliomas.
High SKP2 expression is associated with significantly shortened overall survival.
SKP2 may serve as a potential therapeutic target.
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AI评分总结
SKP2 protein plays a critical role in glioma progression by regulating the cell cycle. This study reveals that high SKP2 expression correlates with poor prognosis in glioma patients, suggesting its potential as a prognostic biomarker and therapeutic target. Analysis of data from TCGA and CGGA databases supports the association of SKP2 with adverse clinical features and survival outcomes, highlighting its significance in glioma biology.