The expression, regulation, and function of human endogenous retroviruses in genitourinary cancers
8.0
来源：
Nature
关键字：
CRISPR
发布时间：
2025-11-29 03:55
摘要：
The review discusses the expression, regulation, and function of human endogenous retroviruses (HERVs) in genitourinary cancers, highlighting their role in oncogenesis and potential as biomarkers and therapeutic targets. It emphasizes the need for further research to validate HERVs in clinical applications, including immunotherapy and early detection strategies.
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domain_focus
1.0分+1.0
business_impact
1.0分+1.0
scientific_rigor
1.5分+1.5
timeliness_innovation
1.5分+1.5
investment_perspective
2.5分+2.5
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1.0分+1.0
team_institution_background
0.5分+0.5
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1.0分+1.0
关键证据
HERVs are implicated in the oncogenesis of various genitourinary cancers.
The review synthesizes fundamental HERV biology with recent advances in their diagnostic and therapeutic applications.
Key clinical translations include ERV-based stratification models predicting immune checkpoint inhibitor response.
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AI评分总结
The review discusses the expression, regulation, and function of human endogenous retroviruses (HERVs) in genitourinary cancers, highlighting their role in oncogenesis and potential as biomarkers and therapeutic targets. It emphasizes the need for further research to validate HERVs in clinical applications, including immunotherapy and early detection strategies.