A bacterial toxin as a novel anti-cancer drug modulating the tumor-microenvironment
8.0
来源：
Nature
关键字：
mRNA
发布时间：
2025-12-01 23:38
摘要：
MakA, a cytotoxin derived from Vibrio cholerae, has been shown to effectively inhibit colorectal cancer growth by modulating the tumor microenvironment and enhancing immune responses. The study reveals that systemic administration of MakA is well-tolerated and promotes immune cell infiltration, particularly monocytes and neutrophils, into the tumor site. These findings suggest that MakA could serve as a promising therapeutic candidate for colorectal cancer, offering a targeted approach with minimal side effects.
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关键证据
MakA administration is non-toxic and does not cause systemic tissue damage.
MakA increases immune cell abundance in the tumor microenvironment.
Direct intratumoral administration of MakA markedly inhibited tumor growth.
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AI评分总结
MakA, a cytotoxin derived from Vibrio cholerae, has been shown to effectively inhibit colorectal cancer growth by modulating the tumor microenvironment and enhancing immune responses. The study reveals that systemic administration of MakA is well-tolerated and promotes immune cell infiltration, particularly monocytes and neutrophils, into the tumor site. These findings suggest that MakA could serve as a promising therapeutic candidate for colorectal cancer, offering a targeted approach with minimal side effects.