PARPs in liver diseases
8.0
来源：
Nature
关键字：
mRNA
发布时间：
2025-12-03 19:33
摘要：
PARPs (Poly(ADP-ribose) polymerases) are critical in liver diseases, including viral hepatitis, liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). This review highlights their roles in disease mechanisms and therapeutic potential, suggesting that PARP inhibitors could be novel treatment strategies. The findings underscore the importance of PARPs in regulating cellular processes and their implications for improving clinical outcomes in liver disorders.
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关键证据
PARPs are implicated in the pathogenesis of various liver diseases, including HCC.
Targeting PARPs may offer novel strategies for treating liver diseases.
The review summarizes the molecular functions of PARPs and their therapeutic potential.
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AI评分总结
PARPs (Poly(ADP-ribose) polymerases) are critical in liver diseases, including viral hepatitis, liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). This review highlights their roles in disease mechanisms and therapeutic potential, suggesting that PARP inhibitors could be novel treatment strategies. The findings underscore the importance of PARPs in regulating cellular processes and their implications for improving clinical outcomes in liver disorders.