Si-Miao-Yong-An decoction suppresses necroptosis by regulating the p53 pathway in myocardial ischemia/reperfusion injury
8.4
来源：
Nature
关键字：
mRNA
发布时间：
2025-12-03 23:40
摘要：
Si-Miao-Yong-An decoction (SMYA) demonstrates significant therapeutic effects on myocardial ischemia/reperfusion (I/R) injury by regulating the p53 signaling pathway. The study reveals that SMYA improves cardiac function, reduces myocardial injury markers, and inhibits necroptosis in a mouse model. Transcriptomic analysis indicates that the p53 pathway is a critical target for SMYA's action, suggesting its potential as a novel treatment for myocardial I/R injury.
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价值维度分析
domain_focus
1.0分+医疗健康领域符合度
business_impact
0.5分+市场潜力
scientific_rigor
1.5分+有具体实验数据支持
timeliness_innovation
1.5分+具有创新性
investment_perspective
2.5分+早期研发阶段
market_value_relevance
1.0分+相关疾病影响广泛
team_institution_background
0.5分+团队背景较强
technical_barrier_competition
0.4分+技术壁垒一般
关键证据
SMYA improved cardiac dysfunction caused by myocardial I/R injury.
Transcriptomic analysis predicted that the p53 signaling pathway may be a potential target.
SMYA suppressed necroptotic processes induced by myocardial I/R injury.
真实性检查
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AI评分总结
Si-Miao-Yong-An decoction (SMYA) demonstrates significant therapeutic effects on myocardial ischemia/reperfusion (I/R) injury by regulating the p53 signaling pathway. The study reveals that SMYA improves cardiac function, reduces myocardial injury markers, and inhibits necroptosis in a mouse model. Transcriptomic analysis indicates that the p53 pathway is a critical target for SMYA's action, suggesting its potential as a novel treatment for myocardial I/R injury.