Reversibility, regulation, and the community of development: the legacy of Sir John B. Gurdon
5.0
来源：
Nature
关键字：
computational pathology
发布时间：
2025-12-04 23:35
摘要：
John B. Gurdon's pioneering research on nuclear transfer and cellular reprogramming has fundamentally altered our understanding of developmental biology. His experiments demonstrated that differentiated cells retain the potential to revert to a pluripotent state, influencing fields such as regenerative medicine and stem cell research. Gurdon's concept of the 'community effect' emphasizes the collaborative nature of cellular differentiation, which has significant implications for tissue engineering and organoid development. His legacy continues to inspire scientists and shape future research.
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关键证据
Gurdon's nuclear-transfer experiments revealed that cellular identity can be reset.
His work established principles that have reshaped modern biology and regenerative medicine.
The community effect he described has implications in tissue engineering and organoid development.
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AI评分总结
John B. Gurdon's pioneering research on nuclear transfer and cellular reprogramming has fundamentally altered our understanding of developmental biology. His experiments demonstrated that differentiated cells retain the potential to revert to a pluripotent state, influencing fields such as regenerative medicine and stem cell research. Gurdon's concept of the 'community effect' emphasizes the collaborative nature of cellular differentiation, which has significant implications for tissue engineering and organoid development. His legacy continues to inspire scientists and shape future research.