Bruceine A protects nuclear receptor 4A1 from ubiquitin-degradation to alleviate mesangial proliferative glomerulonephritis
9.0
来源：
Nature
关键字：
mRNA
发布时间：
2025-12-05 11:32
摘要：
Bruceine A, a natural compound, has been identified as a potential therapeutic agent for mesangial proliferative glomerulonephritis (MsPGN) by stabilizing the nuclear receptor NR4A1. This stabilization inhibits NR4A1 degradation, leading to reduced inflammatory responses and mesangial cell proliferation. The study highlights the significant burden of MsPGN, particularly in China, and proposes a novel approach to treatment that could enhance therapeutic strategies in the biotechnology field.
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关键证据
Bruceine A binds to NR4A1 and inhibits its degradation.
NR4A1 stabilization leads to reduced inflammation and mesangial proliferation.
Study provides a novel therapeutic strategy for MsPGN.
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AI评分总结
Bruceine A, a natural compound, has been identified as a potential therapeutic agent for mesangial proliferative glomerulonephritis (MsPGN) by stabilizing the nuclear receptor NR4A1. This stabilization inhibits NR4A1 degradation, leading to reduced inflammatory responses and mesangial cell proliferation. The study highlights the significant burden of MsPGN, particularly in China, and proposes a novel approach to treatment that could enhance therapeutic strategies in the biotechnology field.