Structure, function, and implications of fucosyltransferases in health and disease
6.0
来源：
Nature
关键字：
computational biology
发布时间：
2025-12-08 19:36
摘要：
Fucosyltransferases (FUTs) are critical enzymes involved in glycosylation, influencing cellular communication and immunity. This review explores their structural and functional characteristics, emphasizing their roles in health and disease, particularly in cancer and immune regulation. Advances in enzyme engineering and the development of FUT inhibitors are highlighted, showcasing their therapeutic potential. The findings underscore the importance of FUTs in various biological processes and their implications for future therapeutic strategies.
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关键证据
Fucosyltransferases are implicated in cancer and immune regulation.
The review highlights advances in structural biology and enzyme engineering.
Current inhibitors and therapeutic strategies targeting FUTs are discussed.
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AI评分总结
Fucosyltransferases (FUTs) are critical enzymes involved in glycosylation, influencing cellular communication and immunity. This review explores their structural and functional characteristics, emphasizing their roles in health and disease, particularly in cancer and immune regulation. Advances in enzyme engineering and the development of FUT inhibitors are highlighted, showcasing their therapeutic potential. The findings underscore the importance of FUTs in various biological processes and their implications for future therapeutic strategies.