CiFi: accurate long-read chromosome conformation capture with low-input requirements
6.5
来源：
Nature
关键字：
computational biology
发布时间：
2025-12-09 07:58
摘要：
CiFi is an innovative method that combines chromosome conformation capture with long-read sequencing to analyze genomic interactions, particularly in complex regions. It requires minimal input, making it suitable for small organisms like mosquitoes. The method enhances haplotype phasing and improves mapping efficiency, potentially transforming genomic studies.
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关键证据
CiFi method enables analysis of genomic interactions across repetitive regions.
Requires as little as 60,000 cells for effective analysis.
Demonstrates improved read-mapping efficiency and coverage.
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AI评分总结
CiFi is an innovative method that combines chromosome conformation capture with long-read sequencing to analyze genomic interactions, particularly in complex regions. It requires minimal input, making it suitable for small organisms like mosquitoes. The method enhances haplotype phasing and improves mapping efficiency, potentially transforming genomic studies.