Multi-omics profiling identifies ESM1 as a key mediator of immunoevasion through the SPP1 pathway in bladder cancer
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来源：
Nature
关键字：
computational pathology
发布时间：
2025-12-09 23:36
摘要：
This study explores the role of Endothelial cell-specific molecule 1 (ESM1) in bladder cancer (BC), revealing its upregulation in cancerous tissues and its association with immune evasion through the SPP1 pathway. Utilizing multi-omics profiling, the research highlights ESM1's potential as a predictive biomarker for immune response and clinical progression in BC patients. The findings suggest that ESM1 could be a valuable target for developing novel diagnostic and therapeutic strategies in bladder cancer management.
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关键证据
ESM1 expression was significantly associated with clinical features and immune cell infiltration.
The study utilized a large sample size and advanced multi-omics techniques.
ESM1 was identified as a potential biomarker for early diagnosis and treatment of bladder cancer.
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AI评分总结
This study explores the role of Endothelial cell-specific molecule 1 (ESM1) in bladder cancer (BC), revealing its upregulation in cancerous tissues and its association with immune evasion through the SPP1 pathway. Utilizing multi-omics profiling, the research highlights ESM1's potential as a predictive biomarker for immune response and clinical progression in BC patients. The findings suggest that ESM1 could be a valuable target for developing novel diagnostic and therapeutic strategies in bladder cancer management.