Bioactive compounds from Sargassum horneri attenuates inflammation and obesity regulating by Nrf2/HO-1 and AMPK signaling pathways
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来源：
Nature
关键字：
mRNA
发布时间：
2025-12-10 23:39
摘要：
Sargassum horneri, a brown seaweed, exhibits significant anti-inflammatory and anti-obesity effects through its bioactive compounds. The study demonstrates its ability to reduce inflammation by inhibiting the NF-κB pathway and activating the Nrf2/HO-1 signaling pathway. In vivo experiments on high-fat diet-induced obese mice revealed that S. horneri treatment led to decreased body weight, fat accumulation, and improved lipid profiles. These findings suggest that S. horneri could serve as a natural therapeutic agent for managing obesity and related inflammatory disorders.
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关键证据
S. horneri extracts significantly reduced body weight and fat accumulation in HFD-induced obese mice.
The study provides evidence for the anti-inflammatory effects through the NF-κB and Nrf2/HO-1 pathways.
S. horneri's bioactive compounds showed antioxidant properties and potential for therapeutic applications.
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AI评分总结
Sargassum horneri, a brown seaweed, exhibits significant anti-inflammatory and anti-obesity effects through its bioactive compounds. The study demonstrates its ability to reduce inflammation by inhibiting the NF-κB pathway and activating the Nrf2/HO-1 signaling pathway. In vivo experiments on high-fat diet-induced obese mice revealed that S. horneri treatment led to decreased body weight, fat accumulation, and improved lipid profiles. These findings suggest that S. horneri could serve as a natural therapeutic agent for managing obesity and related inflammatory disorders.