Urothelium marker UPK2 identifies aggressive colorectal cancers with distinct molecular and histological features
8.0
来源：
Nature
关键字：
mRNA
发布时间：
2025-12-11 23:48
摘要：
UPK2 is a marker for a distinct subset of aggressive colorectal cancers, identified through analysis of large cohorts. Its expression is linked to poor prognosis and specific molecular features, including TP53 mutations and reduced immune cell infiltration. The findings suggest that UPK2 could play a significant role in risk stratification and targeted therapies in precision medicine for colorectal cancer.
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关键证据
UPK2 expression was observed in 12% of colorectal cancers and associated with adverse features.
UPK2 positivity correlated with higher CRC-specific mortality in both cohorts.
UPK2-positive tumors showed reduced infiltration of immune cells, indicating a weaker antitumor immune response.
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AI评分总结
UPK2 is a marker for a distinct subset of aggressive colorectal cancers, identified through analysis of large cohorts. Its expression is linked to poor prognosis and specific molecular features, including TP53 mutations and reduced immune cell infiltration. The findings suggest that UPK2 could play a significant role in risk stratification and targeted therapies in precision medicine for colorectal cancer.