Time-restricted feeding in rodent obesity models: impact on body weights, lipid profile and glucoregulation
5.5
来源：
Nature
关键字：
de novo drug design
发布时间：
2025-12-20 03:47
摘要：
Time-restricted feeding (TRF) has shown significant potential in reducing body weight and improving metabolic health in rodent models of obesity. The review evaluates various TRF protocols, identifying a 10-hour feeding window as the most effective for weight loss and metabolic improvements. The findings suggest that TRF could serve as a practical dietary strategy for obesity management, warranting further research into its mechanisms and applications.
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domain_focus
0.5
business_impact
0.0
scientific_rigor
1.5
timeliness_innovation
1.0
investment_perspective
2.5
market_value_relevance
1.0
team_institution_background
0.0
technical_barrier_competition
0.0
关键证据
TRF was consistently associated with reductions in body weight and total cholesterol.
The most effective identified TRF regimen is a 10-h feeding window over 8 weeks in C57BL/6 mice.
Future research on obesity may take into account the inclusion of different metabolic challenges.
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AI评分总结
Time-restricted feeding (TRF) has shown significant potential in reducing body weight and improving metabolic health in rodent models of obesity. The review evaluates various TRF protocols, identifying a 10-hour feeding window as the most effective for weight loss and metabolic improvements. The findings suggest that TRF could serve as a practical dietary strategy for obesity management, warranting further research into its mechanisms and applications.