Synthesis, biological evaluation, and molecular docking of novel coumarin-based bisimine derivatives
本研究合成了新型的香豆素基双亚胺衍生物，并评估了其抗菌和抗癌活性。结果显示，这些化合物在MCF-7和A549癌细胞系中表现出显著的细胞毒性，部分化合物的活性与多柔比星相当。此外，分子对接分析表明，这些化合物与关键治疗靶点之间存在强有力的相互作用，突显了其在抗生素耐药性和癌症治疗中的潜力。
The impact of Iso-mukaadial acetate on Plasmodium falciparum transcriptional gene regulation
Iso-mukaadial acetate（IMA）是一种从南非药用植物Warburgia salutaris提取的化合物，显示出对疟原虫Plasmodium falciparum的显著抗性。研究通过RNA测序揭示了IMA对疟原虫基因表达的影响，特别是在代谢和DNA复制方面。IMA的IC50值为2.49µM，表明其具有潜在的抗疟药物开发价值。该研究强调了传统药物在现代医学中的应用潜力，支持进一步的生物化学验证和临床前研究。
Double-strand break-free and transgene-free genome editing in the microalga Nannochloropsis oceanica using removable vectors containing the CRISPR base editing system
本研究展示了一种新型的基因编辑技术，利用可移除的CRISPR基础编辑系统在微藻Nannochloropsis oceanica中实现了无双链断裂和无转基因的基因突变。该技术不仅提高了基因编辑的效率，还降低了对宿主细胞的潜在毒性，具有重要的应用价值，尤其是在生物燃料生产领域。
The luminal domain region of Seipin/Fld1 is dispensable for establishing functional ER sites for lipid droplet biogenesis
本研究探讨了Seipin/Fld1的腔域在脂滴生物合成中的作用，发现其并非必需。研究表明，缺失腔域的Seipin能够在酵母中补偿Fld1和Ldb16的功能，并导致TAG水平升高。这一发现为理解脂滴生物合成机制提供了新的视角，并可能推动相关生物技术的应用。
In silico drug sensitivity predicts subgroup-specific therapeutics in medulloblastoma patients
研究开发了DrugSeq平台，能够基于患者特定的基因表达谱预测药物敏感性，针对不同亚组的神经母细胞瘤提供个性化治疗方案。该平台通过分析转录组数据，识别出针对不同亚组的潜在新疗法，具有重要的临床应用价值和国际推广潜力。
Reduced Cas9 transgene silencing by incorporation of intron sequences
该研究探讨了通过引入内含子序列来减少Cas9转基因沉默的机制，发现内含子可以显著提高转基因的表达水平，增强基因编辑的效率。研究表明，不同长度和序列的内含子在减少沉默方面的效果存在显著差异，且结合内含子与其他调控元件（如UCOE）可以协同作用，进一步提高转基因表达的稳定性。这一发现为基因编辑技术的优化提供了新的思路，具有重要的生物技术应用潜力。
A novel lncRNA RP11-544M22.13 enhances glycolysis-induced cisplatin resistance in non-small cell lung cancer
研究揭示了新型长链非编码RNA RP11-544M22.13在非小细胞肺癌中的作用，发现其通过调控SLC2A1表达增强顺铂耐药性。该发现为NSCLC的治疗提供了新的靶点，可能推动小分子药物的开发，具有重要的临床应用潜力。
CAR-macrophages in solid tumors: promise, progress, and prospects
CAR-macrophages (CAR-Ms) are emerging as a promising immunotherapy for solid tumors, combining the innate capabilities of macrophages with engineered chimeric antigen receptors (CARs). This article reviews the progress in CAR-M technology, including preclinical findings and ongoing clinical trials, which suggest a favorable safety profile and potential efficacy against solid tumors. Challenges such as in vivo persistence and scalability are discussed, alongside innovative strategies to enhance CAR-M functionality and address these hurdles. The future of CAR-M therapies looks promising as they advance through clinical testing, potentially transforming cancer treatment.
Cathepsin B as a potential serum biomarker for early diagnosis and progression of diabetic foot ulcer complicated with peripheral vascular disease
CTSB is proposed as a potential serum biomarker for early diagnosis of diabetic foot ulcer (DFU) complicated with peripheral vascular disease (PVD). The study reveals that CTSB levels correlate with the severity of DFU, as indicated by the Wagner grade, and its expression is linked to key clinical indicators. Functional assays demonstrate that CTSB influences angiogenesis in vascular endothelial cells, suggesting its role in disease progression. This research highlights the potential of CTSB for non-invasive monitoring and early intervention in DFU patients.
Localized Wnt-signaling promotes asymmetric NuMA-dependent oriented divisions and unequal apportioning of mitochondria
研究表明，局部Wnt信号通过招募NuMA和微管动力学复合体，促进细胞分裂的方向性，并在细胞分裂中实现线粒体的非对称分配。这一发现为干细胞自我更新和分化提供了新的视角，具有重要的生物医学应用潜力。
m6A regulators-based gene expression pattern is associated with immune microenvironment characteristics in hepatocellular carcinoma
本研究探讨了N6-甲基腺苷（m6A）修饰在肝细胞癌（HCC）中的作用，发现其与免疫微环境特征密切相关。通过分析m6A修饰相关基因，建立了一个风险模型，能够有效预测HCC患者的预后。研究表明，m6A修饰可能通过调节免疫相关基因的表达，影响HCC的免疫逃逸机制，为免疫治疗提供了新的潜在策略。
Cancer-derived fucosylated exosomal miR-6842-3p as a novel marker promotes ESCC angiogenesis and metastasis via the PTEN/AKT/mTOR/IRF1/CXCL10 axis
本研究揭示了肿瘤来源的富含岩藻糖的外泌体miR-6842-3p在食管鳞状细胞癌（ESCC）中的重要作用。miR-6842-3p通过下调PTEN，激活AKT/mTOR信号通路，促进肿瘤的血管生成和转移。该miRNA在ESCC患者的血清外泌体中显著上调，显示出作为早期诊断生物标志物的潜力。研究结果为ESCC的早期检测和靶向治疗提供了新的思路。
Fibrinogen alpha and beta chains as non-invasive predictors of hepatocellular carcinoma progression
Fibrinogen alpha (FGA) and beta (FGB) chains have been identified as promising non-invasive biomarkers for hepatocellular carcinoma (HCC), showing improved diagnostic accuracy compared to traditional markers like α-fetoprotein (AFP). The study highlights significant downregulation of these proteins in HCC, correlating with disease progression and overall survival rates. Their consistent expression patterns across various stages of HCC suggest their potential utility in early diagnosis and monitoring of the disease. The findings underscore the importance of further research to validate these biomarkers in clinical settings.
Overexpressed PRR11-SKA2-miR301a/454 bidirectional transcription unit essentially and coordinately promotes PI3K-AKT pathway activation and lung cancer progression
研究发现PRR11、SKA2及其相关miRNA（miR301a和miR454）在肺癌细胞中共同促进细胞生长和迁移，激活PI3K-AKT信号通路。该转录单元的过表达与肺癌进展密切相关，显示出其作为潜在诊断和治疗靶点的价值。
The CIP2A-TOPBP1 axis facilitates mitotic DNA repair via MiDAS and MMEJ
研究揭示CIP2A-TOPBP1复合体在有丝分裂DNA修复中的关键作用，特别是在BRCA1/2缺陷癌症中的潜在治疗应用。通过CDK1依赖的SLX4磷酸化，CIP2A-TOPBP1轴促进了SMX复合体的招募，从而增强了DNA损伤修复的效率。这一发现为针对高DNA复制压力肿瘤的治疗提供了新的策略，强调了CIP2A作为治疗靶点的重要性。