Cellular activity upregulation of the thermolabile p53 cancer mutant Y220C by small molecule indazole derivatives
本研究探讨了小分子化合物JC16和JC36对p53-Y220C突变体的影响，发现它们能够选择性地诱导该突变体的活性，表现出抗肿瘤潜力。JC16和JC36通过诱导p53-Y220C的构象转变，激活了相关靶基因的转录，显示出良好的细胞毒性和促凋亡效果。这些发现为开发针对p53突变体的治疗策略提供了新的思路，具有重要的临床应用前景。
The RNA N6-methyladenosine methylome coordinates long non-coding RNAs to mediate cancer drug resistance by activating PI3K signaling
该研究探讨了RNA N6-甲基腺苷(m6A)修饰如何通过调控长非编码RNA(lncRNA)介导癌症药物耐药性，尤其是在慢性髓性白血病(CML)中。研究发现，特定lncRNA的上调与对酪氨酸激酶抑制剂(TKI)的耐药性相关，并且通过激活PI3K信号通路促进耐药细胞的生长。该发现为CML患者提供了新的预后指标和潜在的治疗靶点，尤其是针对不携带BCR-ABL突变的耐药患者。
SETD7-mediated H3K4me1 activates ALDH1A3 to drive ferroptosis resistance in esophageal squamous cell carcinoma
SETD7, a histone lysine methyltransferase, is significantly overexpressed in esophageal squamous cell carcinoma (ESCC) and correlates with clinical staging. This study demonstrates that SETD7 promotes ESCC cell proliferation and migration while enhancing resistance to ferroptosis through H3K4me1-mediated activation of ALDH1A3. The findings suggest that targeting SETD7 could provide a novel therapeutic strategy for ESCC, a cancer with poor prognosis and limited treatment options.
MDMX reprograms glycolysis of hepatocellular carcinoma via 14-3-3γ/FOXO1
MDMX plays a crucial role in hepatocellular carcinoma (HCC) by promoting glycolysis through the degradation of FOXO1, a key tumor suppressor. The study demonstrates that MDMX is overexpressed in HCC tissues, correlating with poor patient prognosis, particularly in those with mutant p53. Mechanistically, MDMX enhances the interaction between FOXO1 and 14-3-3γ, leading to FOXO1 degradation and subsequent metabolic reprogramming. These findings suggest that targeting MDMX could provide new therapeutic strategies for HCC treatment.
The transcription factor ZEB2 mediates the antitumor efficacy of tumor-infiltrating lymphocytes in non–small cell lung cancer
ZEB2作为转录因子，在非小细胞肺癌中发挥重要作用，促进CD8+ T细胞的抗肿瘤效应。研究表明，ZEB2通过调控T-bet的表达，影响CD8+ T细胞的分化，可能为免疫治疗提供新的靶点。该研究基于对14名未接受治疗的非小细胞肺癌患者的单细胞RNA测序分析，揭示了ZEB2在肿瘤微环境中的关键作用，具有重要的临床应用潜力。
Pregnane X receptor protects against age-related bone loss in males via PI3K/Akt-mediated inhibition of apoptosis
本研究揭示孕烯X受体(Pxr)在维持骨骼稳态中的关键作用。Pxr缺失导致小鼠出现骨质疏松表型，表现为骨密度降低和骨生成抑制。通过RNA测序，发现Pxr缺失抑制了PI3K/Akt信号通路，导致细胞凋亡和炎症反应增加。相反，Pxr的过表达或激动剂的应用能够改善老年小鼠的骨质量，表明Pxr可能成为治疗年龄相关骨质疏松的新靶点。
Profilin-2 promotes tumour aggressiveness in oral squamous cell carcinoma via HDAC1 modulation: implications for EMT and targeted therapy
PFN2在口腔鳞状细胞癌中被发现是一个重要的肿瘤进展驱动因子，其高表达与淋巴结转移及较差的生存率相关。研究显示PFN2通过调节HDAC1影响细胞增殖和转移，且对HDAC抑制剂SAHA表现出敏感性，提示其在靶向治疗中的潜在应用价值。
Role of B1 antisense RNA on the proliferation and killing tumor ability of aged mouse spleen lymphocytes
B1抗义RNA在老年小鼠脾淋巴细胞中显示出增强增殖和杀伤肿瘤细胞的能力，研究揭示其可能通过调节衰老相关基因和转录因子基因的表达来发挥作用。该研究为肿瘤免疫治疗提供了新的思路，尤其是在老年患者中，具有重要的临床应用潜力。
Kinetoplast DNA structure, RNA editing patterns and small respiratory Complex I in Trypanosoma musculi
该研究详细描述了Trypanosoma musculi的kDNA结构和RNA编辑模式，揭示了其在寄生虫学和生物技术领域的重要性。研究发现了39种minicircle类别，并探讨了其RNA编辑机制及其对小型呼吸复合体I的影响，强调了kDNA异质性在细胞功能和寄生虫适应性中的关键作用。
Targeting the ac4C ‘Writer’ NAT10 enhances pancreatic cancer immunotherapy via dual modulation of CD8+ T cells and tumor cells
NAT10在胰腺癌中发挥关键作用，通过调节ETS2和KRT8的mRNA稳定性促进肿瘤生长和免疫逃逸。研究表明，NAT10的抑制结合抗PD-L1治疗可显著增强抗肿瘤免疫反应，提供了新的治疗策略以克服胰腺癌的免疫抑制微环境。
Research progress on the role and mechanisms of ferroptosis in diabetic wound repair
Ferroptosis, a regulated form of cell death, significantly impacts the healing of diabetic wounds, which are often characterized by delayed recovery and high infection rates. This review discusses the mechanisms by which ferroptosis affects various cell types involved in wound repair, including macrophages, fibroblasts, endothelial cells, and keratinocytes. It also highlights the therapeutic potential of targeting ferroptosis to enhance healing outcomes, emphasizing the need for innovative strategies in managing diabetic wounds.
Co-clinical trial targeting ER, FGFR and CDK4/6 in resistant hormone-positive breast cancer with FGFR alterations
本研究探讨了FGFR扩增的HR+乳腺癌患者在CDK4/6抑制剂治疗后的联合治疗策略，使用rogaratinib、fulvestrant和palbociclib。结果表明，生物标志物驱动的治疗策略在PIK3CA和ESR1野生型患者中显示出显著的进展无生存期(PFS)改善。该研究为FGFR靶向治疗提供了新的临床证据，强调了在早期研发阶段的投资潜力。
Improving early detection of temporomandibular joint involvement in juvenile idiopathic arthritis with a clinically interpretable machine learning model
该研究开发了一种基于XGBoost的机器学习模型，用于预测青少年特发性关节炎患者的颞下颌关节受累情况。模型在独立测试队列中表现出85.5%的准确率，显示出与临床医生评估的高一致性。通过分析标准化的口面检查数据，模型能够识别出与TMJ受累相关的关键临床特征，具有潜在的临床应用价值，能够支持早期诊断和干预。
Development of a wireless bioelectronic actuator for wound healing in a porcine model
本研究开发了一种无线生物电子驱动器，能够在猪模型中进行伤口愈合治疗。该设备通过实时监控和控制药物释放，显示出良好的临床前效果，尤其是在Flx治疗组中，M1/M2巨噬细胞比率的改善表明其在促进伤口愈合方面的潜力。该技术的创新性和应用前景使其成为早期投资的有吸引力的项目。
Radiomics Quality Score 2.0: what changed from version 1.0 and why it matters
Radiomics Quality Score 2.0 (RQS 2.0)的更新旨在提升放射组学在个性化医学中的临床转化能力。新版本强调公平性、可解释性和质量控制，促进方法透明性和临床目的的明确性。通过标准化技术报告和评估新领域，RQS 2.0为放射组学的科学发展提供了重要框架，反映了国际对该领域的需求和标准化趋势。