Progressive changes in phenotype, transcriptome and proliferation capacity characterise continued maturation and migration of intestinal cDCs in homeostasis
本研究探讨了肠道常规树突细胞（cDCs）的动态生命周期，重点关注其成熟、迁移和增殖过程。这些细胞在维持肠道免疫和抗原呈递中发挥着关键作用。研究结果显示，cDCs的高周转率和表型转变对于快速适应免疫挑战至关重要，揭示了其在免疫稳态中的重要性。
A-to-I edited SNHG3 promotes non-small cell lung cancer metastasis by promoting fatty acid oxidation and resisting ferroptosis
研究发现，SNHG3的c.1746 A > I编辑在非小细胞肺癌（NSCLC）中促进转移，且与患者生存率相关。SNHG3ED通过增强脂肪酸氧化和抵抗铁死亡，提升癌细胞的转移能力。此外，针对SNHG3ED的抗病毒治疗显示出克服化疗耐药性的潜力，提供了新的治疗靶点。这一发现为NSCLC的治疗提供了重要的生物标志物和潜在的商业机会。
Targeted deprivation of STAT6 sensitizes acute lymphoblastic leukemia cells to cytarabine in vivo and in vitro: clinical implications
研究发现，靶向STAT6可以显著提高急性淋巴细胞白血病（ALL）细胞对阿糖胞苷的敏感性。STAT6在复发性ALL样本中表达显著降低，且其缺失或抑制能增强细胞对阿糖胞苷的化疗反应。此外，TBX21被确定为与阿糖胞苷敏感性相关的内在标志物。研究结果为克服ALL化疗耐药性提供了新的治疗策略，具有重要的临床应用潜力。
Tissue-specific iron levels modulate lipid peroxidation and the FLASH radiotherapy effect
研究表明，铁在FLASH放疗中扮演关键角色，影响肿瘤细胞的脂质过氧化和细胞死亡机制。通过提高正常组织中的铁水平，FLASH放疗的保护效果可能会被削弱。这一发现为放疗的临床应用提供了新的见解，并可能促进相关治疗策略的开发。
Therapeutic potential of Desmodium styracifolium polysaccharide in attenuating nano-calcium oxalate induced renal injury and fibrosis
Desmodium styracifolium多糖在减轻钙草酸盐诱导的肾损伤和纤维化方面展现出显著的治疗潜力。研究通过生物信息学和实验方法揭示了其作用机制，特别是通过干扰TGF-β信号通路来抑制上皮-间质转化（EMT）。该研究为肾结石相关纤维化的临床治疗提供了新的思路，具有重要的生物技术投资价值。
Bronchopulmonary dysplasia induced by hyperoxia attenuated by A GLP-1 analog, Liraglutide, by regulating the ACE-2/Ang(1-7)/Mas receptor pathway
研究表明，GLP-1类似物Liraglutide通过调节ACE-2/Ang(1-7)/Mas通路，能够减轻高氧诱导的支气管肺发育不良（BPD）。在高氧环境下，Liraglutide显著改善了小鼠的肺泡结构，并降低了炎症因子的水平。这项研究为BPD的治疗提供了新的机制和潜在的治疗策略，具有重要的临床应用前景。
Anti-PD-1 treatment response is associated with the influx of circulating myeloid and T-cell subsets into the metastatic melanoma tumor microenvironment
本研究探讨了抗PD-1治疗反应与转移性黑色素瘤患者肿瘤微环境中髓系细胞和T细胞亚群的关系。结果表明，循环单核细胞衍生的巨噬细胞（MDM）的浸润与治疗反应相关，可能成为预测生物标志物。研究采用高通量成像质谱技术分析了14名患者的免疫细胞组成，发现响应者的MDM浸润显著高于非响应者，提示MDM在免疫治疗中的潜在作用。
Correction: Wnt/ERK/CDK4/6 activation in the partial EMT state coordinates mammary cancer stemness with self-renewal and inhibition of differentiation
该研究探讨了Wnt/ERK/CDK4/6在乳腺癌干细胞中的作用，揭示了其在自我更新和抑制分化中的协调机制。研究涉及多个国际研究机构，具有一定的创新性和研究价值，可能对乳腺癌的治疗策略产生影响。
Physics-informed generative real-time lens-free imaging
GenLFI is a groundbreaking lens-free imaging framework that utilizes a physics-informed neural network to achieve real-time imaging of 3D dynamic samples. This innovative approach significantly enhances the field-of-view and speed of imaging, making it suitable for high-throughput biomedical applications. The framework overcomes traditional limitations of lens-based systems, enabling robust imaging in complex optical environments. With a field-of-view exceeding 550 mm2, GenLFI paves the way for advanced automation in biomedical imaging workflows, offering a scalable solution for monitoring dynamic biological processes.
Integrating single-cell RNA sequencing and artificial intelligence for multitargeted drug design for combating resistance in liver cancer
本研究结合单细胞RNA测序和人工智能，深入分析了肝细胞癌（HCC）的细胞和分子异质性，识别了1178个差异表达基因，并揭示了肝癌的免疫逃逸机制。研究强调了APOE和ALB等基因在预后中的保护作用，以及XIST和FTL在生存预后中的风险作用。通过GNN模型，研究提出了药物重定位的机会，为个性化治疗提供了新的视角。
Echinacea purpurea ameliorates Bleomycin-induced pulmonary fibrosis in rats through modulating NADPH oxidase-4 and endothelin-1/connective tissue growth factor/matrix metalloproteinases signalling axis
Echinacea purpurea has been shown to ameliorate Bleomycin-induced pulmonary fibrosis in rats through modulation of oxidative stress and inflammatory pathways. The study indicates that Echinacea treatment significantly reduces markers of fibrosis and oxidative damage, suggesting its potential as a therapeutic agent for pulmonary fibrosis. This research highlights the need for further investigations to explore the clinical applicability of Echinacea in treating lung diseases.
Preclinical safety and feasibility of a bupivacaine-loaded hydrogel for pain relief after spinal surgery
该研究评估了一种新型bupivacaine负载水凝胶在脊柱手术后的安全性和可行性。结果显示，该水凝胶在局部和系统性方面均表现良好，能够延长药物释放时间，降低系统性药物暴露，且在组织学分析中未显示出显著的毒性反应。这一创新性技术为脊柱手术后的疼痛管理提供了新的解决方案，具有重要的临床应用潜力。
Fully biocompatible, thermally drawn fiber supercapacitors for long-term bio-implantation
THBS fibers represent a significant advancement in biocompatible energy storage for implantable devices, integrating all components into a single fiber architecture. These fibers demonstrate exceptional electrochemical performance and biocompatibility, maintaining stability under physiological conditions. Successful in vivo applications include powering optogenetic devices for nerve stimulation, highlighting their potential in biomedical technology. The thermal drawing process used for fabrication supports scalability, making THBS fibers a promising solution for future implantable bioelectronics.
Compensatory retinal blood flow enhancement in cognitively normal ApoE ε4 carriers
本研究探讨了ApoE ε4基因携带者与非携带者在视网膜血流特征上的差异，发现携带者的foveal avascular zone (FAZ)面积显著减少，而血流密度增加，可能反映出阿尔茨海默病的早期补偿机制。这一发现为开发非侵入性、生物标志物提供了新的视角，具有重要的临床应用潜力，尤其是在阿尔茨海默病的早期筛查和干预方面。
Generative latent diffusion language modeling yields anti-infective synthetic peptides
AMP-Diffusion is a novel generative AI platform designed for the rapid discovery of antimicrobial peptides (AMPs) to combat antibiotic resistance. The platform synthesized 46 peptides from 50,000 in silico designs, with 76% demonstrating antibacterial activity against multidrug-resistant strains. In vivo studies in mice showed that lead peptides effectively reduced bacterial loads, comparable to standard antibiotics. This innovative approach highlights the potential for scalable antibiotic development, making it a promising area for early-stage investment.