Isoallolithocholic acid ameliorates intestinal inflammation via metabolically reprogrammed macrophages
IsoalloLCA, a bile acid metabolite, has been shown to alleviate intestinal inflammation in pediatric patients with inflammatory bowel disease (IBD). The study demonstrates that isoalloLCA reduces TNF production and enhances the expression of anti-inflammatory regulatory T cells in both human and murine models. By metabolically reprogramming macrophages, isoalloLCA enhances oxidative phosphorylation, thereby amplifying its anti-inflammatory effects. This research highlights the potential of isoalloLCA as a promising therapeutic avenue for treating IBD, addressing a significant global health concern.
Sibiriline, a novel dual inhibitor of necroptosis and ferroptosis, prevents RIPK1 kinase activity and (phospho)lipid peroxidation as a potential therapeutic strategy
Sibiriline is a newly identified dual inhibitor of necroptosis and ferroptosis, showing significant potential in treating complex diseases like Parkinson's and cystic fibrosis. The study reveals its mechanisms of action, including inhibition of RIPK1 kinase activity and lipid peroxidation, positioning it as a promising candidate for innovative therapies. Its favorable safety profile and efficacy in preclinical models suggest strong investment potential in the biotechnology sector.
Cathepsin L as a dual-target to mitigate muscle wasting while enhancing anti-tumor efficacy of anti-PD-L1
研究发现，CTSL作为双重靶点，能够在增强抗PD-L1治疗的抗肿瘤效果的同时，减轻因治疗引起的肌肉消耗。该研究通过小鼠模型和临床数据分析，揭示了CTSL在癌症相关肌肉消耗中的关键作用，表明其在未来癌症治疗中的潜在应用价值。
Protein deglycase DJ-1 deficiency aggravates acute viral myocarditis by promoting apoptosis via reducing Dusp1 expression
研究发现，蛋白去糖基化酶DJ-1缺失加重了急性病毒性心肌炎（VMC），通过降低Dusp1表达促进心肌细胞凋亡。DJ-1的过表达能够减轻心肌炎的症状，表明其作为潜在治疗靶点的价值。此研究为心肌炎的治疗提供了新的思路，强调了DJ-1在心脏病理中的重要性。
TRIM63/IRF-8 axis promotes tumor progression and immunosuppression of melanoma with BRAF mutation
研究表明，E3泛素连接酶TRIM63在BRAF突变黑色素瘤中通过促进IRF-8的降解，增强肿瘤进展和免疫抑制。TRIM63的高表达与患者预后不良相关，揭示了其作为潜在治疗靶点的价值。该研究为理解黑色素瘤的分子机制提供了新视角，可能推动相关治疗策略的发展。
ACBP/DBI neutralization for the prevention and treatment of malignant and non-malignant liver diseases
ACBP/DBI中和显示出对多种肝脏疾病的预防和治疗潜力，尤其是肝细胞癌（HCC）。研究表明，ACBP/DBI在HCC患者中升高，与疾病严重程度相关。通过小鼠模型的实验，ACBP/DBI中和能够有效减轻肝脏损伤，具有显著的商业价值和投资潜力。
TRIM25 degrades BRD7 protein stability through the ubiquitin proteasome pathway to promote breast cancer progression and paclitaxel resistance by activating YB1/Bcl-2 transcription axis
TRIM25作为一种E3泛素连接酶，通过降解BRD7蛋白，促进乳腺癌细胞的增殖和紫杉醇耐药性。研究表明，TRIM25在乳腺癌组织中高表达，并与患者的预后密切相关。TRIM25的高表达与乳腺癌的临床阶段及不良预后相关，提示其可能作为潜在的治疗靶点。
Single-cell multiomics analysis reveals CTCF as a key regulator of lung morphogenesis and progenitor maintenance
该研究利用单细胞多组学技术，构建了小鼠胚胎肺发育的基因表达和染色质可及性图谱，揭示了CTCF作为关键调控因子在肺发育和前体维持中的重要作用。研究表明，CTCF通过调节基因表达和染色质动态，影响肺的分支形态发生，提供了对肺疾病机制的深刻理解，具有重要的生物技术研究价值。
NEK7 couples SDHB to orchestrate respiratory chain electron transport homeostasis that impedes liver fibrosis
研究发现NEK7在肝细胞线粒体中发挥关键作用，通过结合SDHB维持线粒体复合体II的稳定性，从而调节电子传输的稳态。NEK7缺失会导致肝纤维化加重，而其过表达则能显著改善肝纤维化。这一发现为肝纤维化的治疗提供了新的潜在靶点，具有重要的临床应用前景。
USP13 dictates Ran turnover and vulnerability to ferroptosis in diffuse large B cell lymphoma (DLBCL)
本研究揭示了去泛素化酶USP13在弥漫性大B细胞淋巴瘤（DLBCL）中的关键作用，USP13通过调节Ran的稳定性影响肿瘤进展。研究表明，USP13的抑制剂Spautin-1能够诱导细胞铁死亡，并与传统化疗药物多柔比星和环磷酰胺联用，显示出良好的协同效果，为DLBCL的治疗提供了新的思路和临床试验的基础。
Low SVEP1 in intrahepatic cholangiocarcinoma mediates phenotype switching-driven metastasis by Jag2/Notch1/Hes5
SVEP1 is identified as a crucial biomarker in intrahepatic cholangiocarcinoma (ICC), with its downregulation linked to poor clinical outcomes. The study demonstrates that decreased SVEP1 expression enhances tumor cell proliferation, migration, and invasion through the activation of the Jag2/Notch1/Hes5 signaling pathway. This research underscores the potential of SVEP1 as a therapeutic target and prognostic factor in ICC, providing insights into the mechanisms driving tumor progression and metastasis.
Targeting RNA polymerase I to boost natural killer cell anticancer activity in multiple myeloma
本研究探讨了RNA聚合酶I抑制剂CX-5461和BMH-21在多发性骨髓瘤中的应用，发现这两种抑制剂通过调节NK细胞激活配体的表达，增强了NK细胞的抗肿瘤活性。BMH-21表现出更强的免疫刺激效果，而CX-5461则通过诱导DNA损伤抑制NK细胞功能。研究结果为多发性骨髓瘤的免疫治疗提供了新的思路，强调了RNA聚合酶I作为治疗靶点的潜力。
MET signaling drives acquired resistance to erdafitinib in muscle-invasive bladder cancer cells
本研究探讨了erdafitinib在FGFR1放大型肌肉侵袭性膀胱癌中的疗效及其耐药机制。结果显示，尽管erdafitinib能够抑制肿瘤生长，但长期使用会导致耐药性的发展，主要通过MET信号通路的激活。研究建议FGFR1和MET的双重靶向可能是克服耐药性的一种有效策略，强调了在膀胱癌治疗中的潜在应用价值。
eIF3i facilitates NELFCD translation to promote metastasis via regulating EMT and invadopodia
研究发现eIF3i通过直接上调NELFCD翻译，促进结直肠癌的上皮-间质转化（EMT）和侵袭小体形成，从而推动肿瘤转移。该通路为抑制结直肠癌转移提供了新的治疗靶点，具有重要的临床应用潜力。
Impact of common variants on brain gene expression from RNA to protein to schizophrenia risk
该研究探讨了常见基因变异如何影响大脑基因表达，并与精神分裂症风险相关。通过对211个前额叶皮层样本的分析，研究发现34%的表达数量性状基因组位点(eQTL)效应未能传播到蛋白水平，揭示了转录后调控的复杂性。研究还识别了74个与精神分裂症相关的风险基因，为理解精神疾病的遗传基础提供了重要线索。