TRIM8-dependent K63-ubiquitinated PGK1 promotes glycolysis and angiogenesis in gastric cancer via interaction with ACAT1
研究发现TRIM8通过K63泛素化PGK1，促进其稳定性，从而增强胃癌细胞的糖酵解和血管生成。TRIM8水平与胃癌患者的血管生成和预后呈正相关，揭示了其作为潜在治疗靶点的重要性。这一发现为胃癌的治疗提供了新的思路，强调了代谢与血管生成之间的联系。
Identification of SLC7A1 as a potential therapeutic target for high-grade meningioma
本研究识别了SLC7A1作为高等级脑膜瘤的潜在治疗靶点，其高表达与患者预后不良相关。通过转录组分析，发现SLC7A1调控多条与肿瘤增殖相关的信号通路。此外，AZ628被预测为针对高SLC7A1脑膜瘤的有效小分子药物，显示出良好的抗肿瘤效果。这些发现为高等级脑膜瘤的治疗提供了新的思路和潜在的药物开发方向。
KDM6A phosphorylation suppresses PER2 to confer a glycolytic vulnerability in HNSCC
本研究揭示了KDM6A的Ser829位点磷酸化在头颈鳞状细胞癌（HNSCC）中的重要作用，表明其通过抑制PER2表达来促进糖酵解和肿瘤生长。研究结果显示KDM6A-pSer829在多种癌症中高表达，提示其作为潜在治疗靶点的价值。这一发现为HNSCC的治疗提供了新的思路，同时也为相关投资提供了良好的商业前景。
Comprehensive map of the regulatory network triggered by MET exon 14 skipping reveals important involvement of the RAS-ERK signaling pathway
该研究构建了METex14Del突变在肺癌中的调控网络，揭示了RAS-ERK信号通路在细胞迁移和侵袭中的关键作用。通过转录组分析，研究发现ETS1、FOSL1和SMAD3等转录因子在HGF刺激下被激活，影响相关靶基因的表达。这一发现为肺癌的靶向治疗提供了新的思路，具有重要的商业投资潜力。
PARP1-TRPM2-PKC cascade distinctly regulates reactive astrogliosis and clasmatodendrosis through NF-κB and AKT pathways in the hippocampus of chronic epilepsy rats
研究发现，PARP1-TRPM2-PKC信号通路在慢性癫痫大鼠海马中调控反应性星形胶质细胞增生和clasmatodendrosis。TRPM2在反应性星形胶质细胞中上调，NAC和PJ34通过上调PHLPP1表达减轻clasmatodendrosis。这一发现为癫痫及其他神经退行性疾病的治疗提供了新的思路。
Atypical cadherin CELSR2 acts as a therapeutic target for glioma through WNT3A/β-catenin signaling
CELSR2 is identified as a critical regulator in glioma development, promoting tumor growth through WNT3A/β-catenin signaling. The study demonstrates that knocking down CELSR2 inhibits glioma cell proliferation and alters key signaling pathways. Additionally, the use of magnetic nanoparticles for targeted delivery of CELSR2-siRNA shows promise as a novel therapeutic strategy for glioma treatment, potentially improving patient outcomes.
Rational design of potent small-molecule SMARCA2/A4 degraders acting via the recruitment of FBXO22
G-6599 is a newly designed monovalent degrader targeting SMARCA2/A4, demonstrating exceptional degradation potency and specificity. It operates through the ubiquitin-proteasome pathway, recruiting the E3 ligase FBXO22, which enhances its therapeutic potential in treating AR-dependent prostate cancers. The study emphasizes the innovative approach of rationally designing degraders from existing ligands, showcasing significant advancements in targeted protein degradation strategies.
Preclinical efficacy and mechanisms of statin-loaded polymeric nanocapsules: a meta-analysis of tumor lipid metabolism inhibition
Statin-loaded polymeric nanocapsules have shown significant antitumor efficacy by enhancing the bioavailability and stability of statins, as evidenced by a meta-analysis of 22 preclinical studies. The findings indicate that these nanocapsules can effectively inhibit tumor growth and weight across various solid tumor models. The study emphasizes the potential of nanomedicine in cancer therapy, particularly for tumors reliant on lipid metabolism, and calls for future clinical trials to further explore their applicability.
Identification of a m6A-immune-related risk model for predicting prognosis, immune microenvironment, and drug responses in acute myeloid leukemia
该研究利用TCGA数据库探讨了m6A修饰与急性髓性白血病（AML）免疫微环境的关系，建立了一个基于EHBP1L1和ZNF385A的风险模型，能够有效预测患者的预后和药物反应。研究发现高风险患者的生存率显著低于低风险患者，并且风险模型在外部验证中表现出良好的预测能力。该模型为AML患者的个性化治疗提供了新的思路和依据。
Mutant p53 protein accumulation is selectively targetable by proximity-inducing drugs
研究开发了一种新型双功能小分子，能够选择性地靶向和杀死TP53突变的癌细胞。该方法利用TP53突变细胞中p53蛋白的丰度，通过诱导接近的机制集中毒性分子，从而实现选择性细胞死亡。这一策略为针对TP53突变的癌症治疗提供了新的思路，具有重要的临床应用潜力。
LINC02159 modulated the glycolysis and proliferation of TNBC cell via targeting miR-1285-3p/G6PI axis
LINC02159在三阴性乳腺癌（TNBC）中被发现显著上调，并与肿瘤进展相关。研究表明，LINC02159通过调节miR-1285-3p与G6PI的相互作用，促进TNBC细胞的增殖和糖酵解。沉默LINC02159可显著抑制TNBC细胞的增殖和迁移，提示其作为潜在治疗靶点的价值。这一发现为TNBC的治疗提供了新的分子机制和靶向策略。
Negative-sense RNA virus nucleocapsid as a versatile platform for gene delivery, vaccine development, and antiviral screening
本研究探讨了负链RNA病毒核壳体作为基因传递、疫苗开发和抗病毒筛选的多功能平台。通过利用病毒的内部复制机制，研究展示了核壳体在细胞内的有效性，提供了一种安全的替代方案，避免了传统疫苗开发中的生物安全风险。此外，核壳体在抗病毒药物筛选中的应用潜力也得到了验证，显示出其在生物技术领域的广泛前景。
Evaluation of salivary and serum Exosomal mRNAs as biomarkers for the diagnosis and prognosis of oral squamous cell carcinoma
研究评估了唾液和血清外泌体mRNA作为口腔鳞状细胞癌(OSCC)的生物标志物，结果显示唾液外泌体中的TNF-α和OAZ1组合具有高达90%的敏感性和80%的特异性，适合早期诊断。该研究强调了印度地区口腔癌的高发病率，支持了生物标志物研究的必要性，为OSCC的非侵入性检测提供了新的方向。
Clinical needs assessment for non-invasive intraoperative bladder volume monitoring devices: a cross-sectional study based on the Kano model
本研究首次应用Kano模型评估非侵入性膀胱容量监测设备的用户需求，强调测量准确性和设备安全性为核心属性。通过对388名外科专业人员的调查，识别出关键设计需求，提供了针对ERAS协议的用户中心技术开发的实证支持。研究结果显示，不同专业组在设备需求上存在显著差异，强调了在高风险手术环境中满足多样化用户需求的重要性。
SARS-CoV-2 NSP14 inhibitor exhibits potent antiviral activity and reverses NSP14-driven host modulation
C10 is identified as a potent and selective inhibitor of SARS-CoV-2 NSP14, demonstrating significant antiviral activity against SARS-CoV-2 and its variants. The compound exhibits a unique mechanism of action by targeting the SAM-binding pocket of NSP14, leading to suppression of viral translation and modulation of host responses. In vivo studies in transgenic mouse models confirm its efficacy, positioning C10 as a promising candidate for further development in antiviral therapies against COVID-19.