Deep learning CT model for stratified diagnosis of pancreatic cystic neoplasms: multicenter development, validation, and real-world clinical impact
PCN-AI is an innovative AI-powered CT model developed for the stratified diagnosis of pancreatic cystic neoplasms (PCNs). In a multicenter study involving 1835 patients, the model demonstrated significant improvements in diagnostic accuracy, enhancing radiologists' performance and reducing interpretation time. The AI model achieved an AUC increase from 0.786 to 0.845, with a 39.3% reduction in clinical workload. This advancement not only aids in early cancer detection but also streamlines clinical workflows, showcasing its potential impact in oncology.
A multimodal multipath AI system for assessing PAH after VSD correction on echocardiography and chest radiography images
该研究开发了一种多模态多路径人工智能系统（MMAI），用于评估心室间隔缺损（VSD）修复后小儿肺动脉高压（PAH）。通过分析1316名患者的数据，MMAI系统在图像分割和分类任务中表现出色，AUC和准确率均超过90%。研究强调了AI在提高PAH早期检测和个性化治疗中的潜力，尤其是在资源有限的环境中。
Integrating spatial and chemical information enhances differentiation of non-alcoholic steatohepatitis states in Raman imaging
本研究提出了一种新颖的Raman成像分析方法，结合空间和化学信息，以提高对非酒精性脂肪肝病（NAFLD）不同病理状态的区分能力。通过对NAFLD模型的实验，研究表明该方法能够有效识别正常、非酒精性脂肪肝（NAFL）和非酒精性脂肪肝炎（NASH）等状态，具有重要的临床应用潜力。
Nobiletin and polydatin synergistically alleviate triple-negative breast cancer liver metastasis via suppressing ECM1a-mediated fatty acid biosynthesis
本研究探讨了nobiletin和polydatin的组合在三阴性乳腺癌肝转移中的协同作用，发现ECM1a在肝转移潜力与脂肪酸生物合成之间起关键作用。研究表明，该组合通过下调PI3K/AKT/mTOR/SREBPs信号通路，显著抑制肿瘤的脂肪酸生物合成，显示出作为BCLM新型治疗选择的潜力。
Demonstration of chemotherapeutic-mediated changes in meningeal lymphatics in vitro, ex vivo, and in vivo
该研究通过体外、体外和体内模型探讨了化疗对脑膜淋巴管的影响，发现化疗药物（如多西他赛）导致脑膜淋巴管的形态变化，并与认知功能障碍相关。这一发现强调了脑膜淋巴管在化疗相关认知障碍中的潜在作用，提供了新的研究模型和临床应用的可能性。
AI抗体2025全景：当David Baker失去领先，谁能重塑AI抗体设计的逻辑？
AI抗体设计领域正经历快速变革，多个新兴模型如RFantibody、IgGM和Chai-2等展现出显著的效率提升和创新能力。中美团队在技术和商业模式上各有侧重，推动了行业的发展。AI技术的普及可能重塑抗体发现的商业逻辑，未来的竞争将集中在数据质量和疾病生物学理解上。
90 岁物理学家亲测线粒体疗法，挑战年龄极限，要成为史上最年长的“年轻人”
90岁物理学家克拉默参与了一项线粒体疗法的临床试验，旨在通过生物反应器培育的线粒体逆转衰老进程。该疗法通过替换衰老细胞的线粒体，提升细胞能量代谢，显示出显著的潜力。研究表明，线粒体疗法可能为抗衰老提供新的治疗思路，并吸引了多方关注与投资。
Multi-omics reveal critical roles of phosphatidylcholine and sphingomyelin in antipsychotic efficacy for schizophrenia
本研究通过多组学分析，探讨了磷脂酰胆碱和鞘磷脂在抗精神病药物疗效中的关键作用。研究分析了208名精神分裂症患者在接受6周帕利哌酮治疗后的反应，发现高水平的磷脂酰胆碱和鞘磷脂与更好的疗效相关。通过机器学习和多组学模型，研究成功预测了抗精神病药物的疗效，显示出该领域的创新潜力和商业价值。
Intracellular pH dynamics respond to extracellular matrix stiffening and mediate vasculogenic mimicry through β-catenin
本研究探讨了细胞内pH动态如何响应细胞外基质刚度的变化，并通过β-catenin介导肿瘤血管模仿现象。研究发现，增加的基质刚度会降低细胞内pH，从而促进肿瘤细胞的血管模仿表型。通过使用可调刚度的水凝胶模型，研究揭示了细胞内pH作为肿瘤细胞对机械环境响应的关键调节因子，提供了针对肿瘤治疗的新思路。
Glutamine: a new strategy for targeted metabolic therapy in the tumor microenvironment
该研究探讨了谷氨酰胺在肿瘤微环境中的关键作用，强调其对肿瘤细胞生长和代谢的重要性。研究表明，肿瘤细胞在竞争谷氨酰胺方面具有绝对优势，这为开发针对谷氨酰胺代谢的抗癌治疗提供了理论基础。文章总结了当前针对谷氨酰胺代谢的抗癌药物，并指出其在未来临床治疗中的重要性。
Mesenchymal stromal cells induce neutrophil aggregation and extracellular vesicle storms for systemic lupus erythematosus
本研究揭示了间充质干细胞（MSC）在系统性红斑狼疮（SLE）治疗中的创新机制，MSC通过诱导受体中性粒细胞聚集和外泌体风暴，显著改善SLE患者的临床效果。研究表明，EV风暴的水平与MSC治疗的疗效呈正相关，可能成为预测MSC疗效的早期指标。这一发现为MSC在自身免疫疾病治疗中的应用提供了新的视角。
Apomorphine is a novel necroptosis inhibitor targeting mixed lineage kinase domain-like protein oligomerization
Apomorphine (APO), an FDA-approved drug for Parkinson's disease, has been identified as a novel necroptosis inhibitor targeting mixed lineage kinase domain-like protein (MLKL) oligomerization. This study demonstrates that Ox-APO, the oxidized form of APO, effectively inhibits necroptosis in murine models of inflammatory bowel disease and liver injury. The findings suggest that Ox-APO could serve as a promising candidate for treating necroptosis-related diseases, highlighting its potential for broader therapeutic applications.
Central Zika virus infection causes hypothalamic inflammation and persistent insulin resistance in adult mice
Zika virus (ZIKV) infection in adult mice results in significant hypothalamic inflammation and persistent insulin resistance, even after acute inflammation resolves. The study demonstrates that ZIKV invades the hypothalamus, triggering inflammatory responses that disrupt insulin signaling and alter neuropeptide expression critical for glucose homeostasis. Despite the resolution of inflammation, insulin resistance persists, suggesting a potential link between viral infections and long-term metabolic disorders such as obesity and type 2 diabetes. These findings underscore the importance of understanding the metabolic consequences of ZIKV neuroinvasion.
Nobiletin (NOB) nanoparticles ameliorate chronic paradoxical sleep deprivation (PSD)-induced cognitive deficits in rats
Nobiletin (NOB) nanoparticles have been shown to alleviate cognitive deficits induced by chronic paradoxical sleep deprivation (PSD) in rats. The study reveals that NOB nanoparticles enhance cognitive performance by modulating microglial polarization and regulating the BMAL1/SIRT1/E2F1 axis. This research highlights the potential of NOB nanoparticles as a therapeutic strategy for cognitive impairments associated with sleep disorders, suggesting significant implications for future neuroprotective therapies.
表观遗传太玄幻？清华大学AI单细胞大模型EpiAgent，破解生命密语！
清华大学研发的EpiAgent模型在表观遗传学领域取得突破，能够自动识别细胞类型、修复稀疏数据并预测细胞反应，展现出AI在生命科学中的巨大潜力。该模型的应用不仅有助于药物靶点的发现，还能模拟基因调控异常，为未来的生物医学研究提供了新的工具和视角。