A programmable pAgo nuclease with high activity and specificity for efficient DNA and RNA manipulation
GgeAgo是一种新型的可编程Argonaute核酸酶，具有高效的DNA和RNA切割能力，能够在广泛的温度和条件下工作。研究表明，GgeAgo在生物技术应用中具有重要潜力，包括DNA克隆和核酸检测。其高特异性和灵活性使其成为开发新型核酸操作工具的有前景的候选者。
Aberrant lipid metabolism renders an aggressive behavior of T-lymphoblastic lymphoma in a MASH model
研究发现，脂质代谢异常促进了T-淋巴母细胞淋巴瘤的侵袭性生长，Wnt/β-连环蛋白信号通路可能是其致癌机制之一。通过建立MASH小鼠模型，研究表明，Fenofibrate作为PPAR-α激动剂，能够有效抑制肝脏淋巴瘤的浸润，提示其在淋巴瘤治疗中的潜在应用价值。
Oxidative stress reactivates androgen receptor signaling via USP36 to drive castration resistance in prostate cancer
该研究探讨了氧化应激如何通过去泛素化酶USP36重激活前列腺癌中的雄激素受体信号通路，揭示了其在前列腺癌进展中的关键作用。研究发现低剂量的H2O2能够增强前列腺癌细胞的存活率，并促进雄激素受体及其靶基因前列腺特异性抗原的表达。这一机制为治疗去势抵抗性前列腺癌提供了新的潜在策略，具有重要的临床和商业价值。
The mechanism of luteolin suppressing pancreatic cancer (PC) via cyclin B1 (CCNB1)-mediated signalling
Luteolin effectively suppresses pancreatic cancer growth by targeting cyclin B1 (CCNB1), leading to cell cycle arrest and apoptosis. The study utilized various assays, including patient-derived organoids and xenograft models, to demonstrate luteolin's potential as a therapeutic agent. By disrupting the CCNB1/CDK1 complex, luteolin induces significant anti-tumor effects, highlighting its promise in addressing the challenges of pancreatic cancer treatment.
CCDC141 is a Connectin/Titin and Nesprin-1 binding protein that adapts cardiomyocytes to mechanical stress
CCDC141 is identified as a novel binding protein that interacts with connectin and nesprin-1, playing a critical role in the adaptation of cardiomyocytes to mechanical stress. The knockout of CCDC141 leads to significant cardiac dysfunction, including hypertrophy and increased susceptibility to fatal arrhythmias under mechanical stress. This research highlights CCDC141's potential as a therapeutic target for improving cardiac function in heart diseases.
Preliminary exploration of the role of fibrinogen-like protein 2 in neuroblastoma
本研究初步探讨了FGL2在神经母细胞瘤中的作用，发现FGL2的低表达与患者的不良预后显著相关。研究表明，FGL2通过抑制NF-κB信号通路，降低神经母细胞瘤细胞的增殖、迁移和侵袭能力，提示FGL2可能作为神经母细胞瘤的预后生物标志物和潜在治疗靶点。
Knockdown of GCNT2 promoted osteoblast differentiation by activating PI3K/AKT/mTOR pathway in osteoblasts
本研究探讨了GCNT2在骨质疏松症中的作用，发现其敲低能够促进骨母细胞的分化，并通过激活PI3K/AKT/mTOR信号通路发挥作用。研究结果表明，GCNT2可能成为骨质疏松症的新治疗靶点，具有重要的临床应用潜力。
NLRP3-induced systemic inflammation controls the development of JAK2V617F mutant myeloproliferative neoplasms
本研究探讨了NLRP3炎症小体在JAK2V617F突变的骨髓增生性肿瘤中的作用，发现NLRP3对肿瘤发展至关重要。通过基因删除和药物抑制NLRP3，研究表明其在肿瘤细胞增殖和相关症状中的关键作用。抑制NLRP3不仅减轻了血小板增多症和脾肿大，还显著降低了骨髓纤维化的发生。这些发现为JAK2V617F突变患者提供了新的治疗策略，表明NLRP3是一个有前景的治疗靶点。
Identification of miR-940 and associated gene features as novel biomarkers for early detection of cerebral hemorrhage
本研究通过生物信息学和实验验证，识别出miR-940及其相关基因特征作为脑出血的潜在生物标志物。研究表明，miR-940在调节线粒体代谢和免疫细胞动态中发挥关键作用，可能为脑出血的早期诊断和治疗提供新靶点。该发现为理解脑出血的病理机制提供了新的视角，并可能影响未来的治疗策略。
EZH2 expression in hepatocellular carcinoma and its relationship with circadian rhythm-related genes
The study investigates the role of EZH2 in hepatocellular carcinoma (HCC), revealing its overexpression correlates with advanced tumor stages and poor patient prognosis. It establishes a link between EZH2 and circadian rhythm-related genes, suggesting that EZH2 may influence tumor progression through these pathways. The research utilizes data from TCGA and GEO databases, highlighting the potential of EZH2 as a prognostic biomarker and therapeutic target in HCC, with implications for personalized medicine.
Single-cell and bulk transcriptomics reveal Fusobacterium nucleatum promotes colorectal cancer metastasis by upregulating LAMC2 in in vitro and in vivo models
本研究揭示了Fusobacterium nucleatum通过上调LAMC2促进结直肠癌（CRC）转移的机制，表明LAMC2可能成为潜在的治疗靶点。研究显示，LAMC2在CRC组织中的高表达与患者预后不良显著相关，强调了肠道微生物在癌症进展中的重要作用。
Transcription factor CEBPA suppresses sepsis induced lung injury by activating SIRT4 transcription
本研究探讨了转录因子CEBPA和SIRT4在脓毒症诱导的急性肺损伤中的作用。结果显示，CEBPA通过激活SIRT4的转录，显著减轻了LPS诱导的细胞损伤，促进了细胞存活，减少了凋亡和炎症。这一发现为急性肺损伤的治疗提供了新的生物学靶点，具有重要的临床应用潜力。
A biomimetic senotherapy replenishing MAT2A promotes wound regeneration in preclinical models
该研究揭示了甲硫氨酸腺苷转移酶2A（MAT2A）在糖尿病伤口愈合中的关键作用，强调其在细胞衰老和慢性炎症中的影响。研究开发了一种基于生物仿生策略的纳米颗粒，用于靶向递送MAT2A自扩增RNA，显著促进伤口再生。该发现为糖尿病伤口治疗提供了新的潜在靶点，具有重要的临床应用前景。
Exploring tumor dynamics and responses of prostate cancer to IL-27 based treatment combinations through biodynamic imaging and RNA sequencing analyses
该研究探讨了IL-27与化疗药物（如卡博替尼和多西他赛）联合治疗前列腺癌的效果，采用生物动态成像和RNA测序技术，揭示了肿瘤微环境的动态变化。研究表明，IL-27能够调节肿瘤微环境，增强免疫反应，从而提高治疗效果。这一创新方法为前列腺癌的治疗提供了新的思路，具有重要的临床和商业价值。
Serotonin receptor type 7 (5-HT7) promotes colorectal cancer progression by activating Wnt/β-catenin signaling via interacting with CK1ε
研究发现5-HT7受体在结直肠癌中显著上调，促进肿瘤细胞增殖、迁移和侵袭。通过与CK1ε相互作用，5-HT7激活Wnt/β-catenin信号通路，推动肿瘤进展。该发现为靶向5-HT7提供了新的治疗潜力，具有重要的临床应用价值。