Antigen-specific CD8+CD39+ cytotoxic T cell density in the microenvironment of hepatocellular carcinoma predicts patient survival
研究发现，肝细胞癌微环境中抗原特异性CD8+CD39+细胞的密度与患者生存期显著相关。通过对100名接受根治性肝切除术的患者进行分析，结果显示，肿瘤周围高密度的CD8+CD39+ T细胞与更长的生存期相关。这一发现为个性化治疗策略提供了新的预后工具，可能对肝癌的免疫治疗产生重要影响。
Translation of miRNA blood-based discovery to molecular testing for clinical diagnosis of endometriosis
本研究探讨了一种基于血液的miRNA检测方法，用于诊断子宫内膜异位症，显示出超过90%的准确性。通过对20名患者和20名对照的血清进行miRNA测序，研究识别出潜在的诊断生物标志物，并利用机器学习模型进行验证。研究结果表明，miRNA检测作为一种非侵入性诊断工具，具有显著的临床应用潜力，尤其是在提高子宫内膜异位症的早期诊断率方面。
Transcriptomic exploration of key genes related to mitochondria and ferroptosis in inflammatory bowel disease and experimental validation
This study explores the roles of mitochondrial dysfunction and ferroptosis in inflammatory bowel disease (IBD), identifying four key genes: AQP8, ACSF2, ACSL4, and IL1B. These genes were validated through machine learning and experimental methods, showing strong diagnostic potential with an ANN model. The research highlights the interconnectedness of these genes with immune responses and metabolic pathways, suggesting new avenues for therapeutic interventions in IBD.
RASH3D19 mediates RAS activation through a positive feedback loop in KRAS-mutant cancer
RASH3D19在KRAS突变癌中通过正反馈环介导RAS激活，研究显示其遗传缺失可抑制癌细胞生长并增强对KRAS抑制剂的敏感性。这一发现为治疗KRAS突变相关癌症提供了新的靶点，具有重要的临床和商业潜力。
Inhibition of scheggia/SLC25A1 citrate transporter alleviates XPD deficits
研究发现，抑制线粒体柠檬酸转运蛋白SLC25A1可以改善XPD突变细胞在紫外线照射下的生存能力。这一发现揭示了XPD与SLC25A1之间的遗传相互作用，表明SLC25A1可能成为治疗干预的新靶点，尤其是在与紫外线损伤相关的XPD综合症中。该研究为生物技术领域的早期投资提供了潜在机会。
A bacterial toxin as a novel anti-cancer drug modulating the tumor-microenvironment
MakA, a cytotoxin derived from Vibrio cholerae, has been shown to effectively inhibit colorectal cancer growth by modulating the tumor microenvironment and enhancing immune responses. The study reveals that systemic administration of MakA is well-tolerated and promotes immune cell infiltration, particularly monocytes and neutrophils, into the tumor site. These findings suggest that MakA could serve as a promising therapeutic candidate for colorectal cancer, offering a targeted approach with minimal side effects.
Sustainable and portable CRISPR-based diagnostics for high-sensitivity Mpox detection
Kairo-CONAN is a novel CRISPR-Cas3-based diagnostic platform designed for high-sensitivity detection of monkeypox (Mpox). This portable system utilizes a disposable hand warmer for device-free operation and incorporates freeze-dried reagents for stability, making it suitable for low-resource settings. The platform aligns with the G7's 100 Days Mission, addressing urgent public health needs by providing rapid and reliable diagnostics in outbreak scenarios. Its innovative design and high specificity position Kairo-CONAN as a transformative tool for global health initiatives.
Prognostic and immunological potential of AC012236.1/hsa-miR-30d-5p CeRNA of AVEN by integrated analysis of single-cell and bulk RNA-seq in lung adenocarcinoma
AVEN被确认是肺腺癌（LUAD）的重要预后生物标志物，其表达水平与患者的生存率密切相关。研究通过整合单细胞和大规模RNA测序数据，揭示了AVEN在LUAD中的调控机制及其在肿瘤免疫微环境中的作用。此外，构建的lncRNA-AC012236.1/hsa-miR-30d-5p/AVEN的ceRNA网络为LUAD的治疗提供了新的靶点，显示出AVEN在临床应用中的潜力。
A simplified wearable device powered by a generative EMG network for hand-gesture recognition and gait prediction
研究提出了一种基于生成电肌图（EMG）网络的可穿戴设备，能够在减少传感器数量的同时，保持高效的手势识别和步态预测性能。这种设备在准确性上与传统高密度传感器相当，适用于健康监测、假肢、运动和人机接口等多个领域，展示了其广泛的应用潜力和市场价值。
Treadmill exercise alleviates depression in female mice induced by chronic unpredictable mild stress through the Inhibition of cGAS-STING signalling
研究发现，慢跑运动能够显著缓解慢性不可预测轻度压力（CUMS）诱导的抑郁样行为，主要通过抑制cGAS-STING信号通路来实现。这一机制涉及减少神经炎症和恢复神经递质平衡，为女性抑郁症的非药物干预提供了新的理论基础。
Introduction of Cistanche phelypaea fatty acids as a new natural neurotrophic supplement by evaluating its effects in normal and Alzheimer’s diseased rats
Cistanche phelypaea fatty acids have been identified as a potential natural neurotrophic supplement, showing significant effects on memory and behavior in both normal and Alzheimer’s disease rat models. The study highlights the fatty acids' ability to reduce levels of acetylcholine esterase and β-amyloid, suggesting a protective role against neurodegeneration. Given the increasing incidence of Alzheimer’s disease, this research points to a promising avenue for developing new therapeutic strategies targeting cognitive decline.
Large language models in biomedicine and healthcare
Large language models (LLMs) are revolutionizing biomedicine and healthcare by improving clinical diagnostics, enhancing drug discovery, and facilitating patient engagement. They analyze vast amounts of unstructured data, leading to more accurate diagnoses and personalized treatments. However, the integration of LLMs faces challenges such as data privacy, algorithmic bias, and the need for ethical considerations. Addressing these issues is crucial for the safe and effective use of LLMs in clinical settings.
MAIA: a collaborative medical AI platform for integrated healthcare innovation
MAIA is a collaborative medical AI platform designed to integrate AI tools into clinical workflows, enhancing the detection and segmentation of brain and bone metastases. It supports collaborative research and development, providing a modular, scalable environment for AI model development and deployment. Implemented at KTH and Karolinska University Hospital, MAIA facilitates interdisciplinary collaboration, promoting innovation in medical AI applications while ensuring compliance with ethical and regulatory standards.
SCOPE-MRI: Bankart lesion detection as a case study in data curation and deep learning for challenging diagnoses
该研究介绍了ScopeMRI数据集及其在Bankart损伤检测中的应用，展示了深度学习在医疗影像中的潜力。研究表明，深度学习模型在标准MRI上检测Bankart损伤的敏感性和特异性与放射科医师解读MRI动脉造影相当，提供了一种非侵入性的诊断方法。ScopeMRI数据集的发布将促进未来在肌肉骨骼影像领域的研究，推动相关技术的临床应用。
Computationally-designed aptamers targeting RAD51-BRCA2 interaction impair homologous recombination and induce synthetic lethality
本研究开发了一种计算设计的适配体，针对RAD51与BRCA2的相互作用，显著影响同源重组过程，增强癌细胞对化疗药物的敏感性。适配体通过改变RAD51的核定位，降低DNA修复效率，诱导合成致死效应，尤其在胰腺癌细胞中表现出良好的效果。这一创新方法为癌症治疗提供了新的可能性，特别是结合PARP抑制剂的应用。