Graph based link prediction for epilepsy drug discovery
本研究提出了一种基于图的计算框架，利用图神经网络（GNN）预测植物化学物质与蛋白质的相互作用，旨在开发新的抗癫痫药物。研究表明，该模型在准确性（0.9778）、精确度（0.9574）和F1分数（0.9782）上表现优异，强调了阿育吠陀在癫痫治疗中的潜力，具有重要的市场价值和创新性。
Thalamic nuclei volume changes associated with cognitive and motor manifestations of Parkinson’s disease
本研究探讨了帕金森病患者丘脑核团体积变化与认知和运动症状的关系。结果显示，特定丘脑核团的体积变化与认知功能（如蒙特利尔认知评估）和运动障碍（如MDS-UPDRS-III）显著相关。研究利用高分辨率MRI和部分最小平方分析，分析了247名参与者的数据，强调了丘脑在帕金森病中的重要作用。这些发现为理解帕金森病的病理生理提供了新的视角，并可能为未来的干预策略提供依据。
Brain modes of resonance estimated by a biophysical multi-compartment finite elements model
该研究利用有限元模型探讨了大脑的共振模式，揭示了大脑的机械特性如何影响其功能活动。研究表明，脑组织的物理特性对共振模式有显著影响，可能为神经疾病的诊断和治疗提供新的思路。通过与现有文献的对比，研究强调了模型复杂性和边界条件对结果的重要性，推动了对大脑功能与结构之间关系的理解。
Analysis of perioperative risk factors and development of predictive models for complications following CT guided microwave ablation of pulmonary nodules
本研究分析了117名接受CT引导下微波消融的肺结节患者的围手术期风险因素，识别出BMI、肺气肿、肺扩散能力降低等独立风险因素，并开发了相应的预测模型。研究结果显示，模型在预测并发症方面具有较高的准确性，ROC曲线下的AUC值为0.863，表明其在临床决策中的潜在应用价值。
CCAAT/enhancer binding protein beta (C/EBPβ) regulates the formation of the ovarian reserve
研究表明CCAAT/增强子结合蛋白β（C/EBPβ）在小鼠卵巢储备形成中起关键调节作用。C/EBPβ的表达在卵泡形成过程中显著增强，其缺失会抑制卵泡形成，影响NTRK信号通路。该研究为理解卵巢发育及生育能力提供了新的视角，具有重要的生物技术研究价值。
In vitro and in vivo investigation of the capacity of mulberroside A to inhibit senescence
Mulberroside A, a compound derived from mulberry, exhibits significant anti-aging properties by promoting endothelial cell proliferation and reducing senescence biomarkers in both in vitro and in vivo studies. The research highlights its potential therapeutic applications in combating age-related diseases, emphasizing the importance of natural products in health maintenance and longevity.
Computer-aided screening of marine fungal metabolites as potential inhibitors of new Delhi metallo-beta-lactamase-1
本研究利用计算机辅助筛选海洋真菌代谢物，发现其可能作为新德里金属β-内酰胺酶-1的抑制剂。研究表明，58种代谢物的结合亲和力超过了参考药物，显示出良好的药物相容性和生理特性。此类代谢物的开发对抗生素耐药性问题具有重要的临床意义，值得进一步的实验验证。
Adiponectin receptor agonist, AdipoRon, restores hepatic clock gene expression in PCOS-associated NAFLD
AdipoRon, an adiponectin receptor agonist, has shown promising results in restoring hepatic clock gene expression and improving metabolic dysfunction in a PCOS-associated NAFLD rat model. The study highlights its potential therapeutic benefits, including alleviating insulin resistance and lipid accumulation, which are critical in managing PCOS-related complications. These findings suggest that AdipoRon could be a valuable candidate for further development in treating metabolic disorders linked to PCOS.
Garcinone D mitigates amyloid β42-Induced neurotoxicity: unravelling mechanisms of neuroprotection
Garcinone D, a bioactive xanthone from mangosteen, exhibits significant neuroprotective effects against amyloid β42-induced neurotoxicity in SH-SY5Y cells. The study reveals that GD enhances cell viability, stabilizes mitochondrial function, and activates antioxidant pathways while inhibiting apoptotic markers. These findings suggest GD's potential as a therapeutic candidate for Alzheimer's disease, addressing multiple aspects of cellular damage associated with neurodegeneration. Further research is warranted to explore its therapeutic applications.
OGT-mediated O-GlcNAc of FOXO1 promotes the progression of neonatal heart failure via regulating pyroptosis
本研究探讨了OGT介导的O-GlcNAc在新生儿心衰中的作用，发现其在心衰患者中显著升高，并通过调节焦亡促进心衰进展。研究表明，OGT缺失可抑制心衰相关的细胞死亡，且在动物模型中OGT抑制减轻了心肌损伤和功能障碍。这些发现为新生儿心衰的治疗提供了新的思路，具有重要的临床和商业潜力。
A proof of concept study of 18F-FDG PET/CT patient-level radiomics identify refractory/relapsed diffuse large B-cell lymphoma
本研究探讨了18F-FDG PET/CT影像学在复发/难治性大B细胞淋巴瘤患者中的应用，利用放射组学分析识别出三种亚型，显示出不同的临床特征和预后。研究结果表明，结合放射组学评分与临床数据的机器学习模型在预测患者预后方面具有显著优势，可能为个性化治疗提供新的思路。
Evaluating the diagnostic significance of biomarkers in ventriculitis through a multivariate correlation study in a tertiary care center
本研究评估了脑室炎患者脑脊液中的生物标志物，发现IL-6、IL-10和TNF-α在确诊患者中显著升高，具有良好的诊断性能。研究还探讨了微生物谱及其抗生素敏感性，揭示了抗生素耐药性的问题，强调了早期干预的重要性。该研究为印度地区脑室炎的诊断和管理提供了重要数据，具有较高的临床应用价值。
The therapeutic potential of beta-carotene against neuroinflammation and amyloid beta in SH-SY5Y cells
研究表明，β-胡萝卜素在SH-SY5Y神经母细胞瘤细胞中具有显著的神经保护作用，能够通过抑制凋亡和炎症、增强抗氧化防御以及减少淀粉样β蛋白的产生来对抗阿尔茨海默病。该研究强调了β-胡萝卜素作为潜在治疗候选药物的价值，尤其是在应对日益严重的神经退行性疾病方面。
Social memory engram formation impairment in neuroligin-3 R451C knock-in mice is caused by disrupted prefrontal NMDA receptor-dependent potentiation
本研究探讨了自闭症谱系障碍中社交记忆缺陷的机制，发现NMDAR依赖的长时程增强在社交记忆形成中至关重要。使用Neuroligin-3 R451C敲入小鼠模型，研究表明D-cycloserine能够有效改善社交记忆缺陷，提出了其作为潜在治疗手段的可能性。
Murraya koenigii methanolic extract inhibits bacterial growth and biofilm of Staphylococcus aureus and Enterococcus faecalis
Murraya koenigii methanolic extract (MKM) exhibits significant antibacterial activity against Staphylococcus aureus and Enterococcus faecalis, with minimum inhibitory concentrations of 39 µg/mL and 48.8 µg/mL, respectively. The extract disrupts biofilm formation and reduces extracellular polymeric substance production, indicating its potential as a novel therapeutic agent against biofilm-associated infections. Molecular docking studies reveal strong binding affinities of MKM-derived compounds with key biofilm-related proteins, suggesting a promising avenue for combating antibiotic resistance.